Indications
Therapeutic Class
Pharmacology
Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Clopidogrel also inhibits platelet aggregation induced by agonists other than ADP.
Aspirin inhibits platelet aggregation by irreversible inhibition of platelet cyclooxygenase and thus inhibiting the generation of thromboxane A2 a powerful inducer of platelet aggregation and vasoconstriction.
Dosage & Administration
The recommended dose is one tablet once daily. Orally it is only recommended for adult.
Use in hepatic impaired patients: Experience in limited in patients with severe hepatic disease, who may have bleeding diatheses. Clopidogrel should be used with caution in this population.
Interaction
Contraindications
Side Effects
Pregnancy & Lactation
Pregnancy: There are, however, no adequate and welcontrolled studies in pregnant women. It should be avoided during last 3 months of pregnancy and should be used during pregnancy only if clearly needed.
Lactation: As Aspirin is excreted in breast milk, it should not be taken by patients who are breastfeeding.
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